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Faces of DARPP-32: Master Signaling Mediator in the Brain?
As a major target for dopamine-activated adenylyl cyclase and protein kinase A in the striatum, DARPP-32 plays a central role in regulating the efficacy of dopaminergic neurotransmission and can act e...
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The Contributions of Radiation Oncology to the Medical World
Oncology is a branch of medicine that studies cancerous tumors and develops methods and techniques for treatment. Those who practice oncology are known as oncologists.
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Data Validation through Tissue Analysis
IMGENEX History-Array tissue array slides are a simple, powerful, inexpensive, yet highly efficient method for expression analysis or localization studies of molecular targets at the DNA, RNA or prote...
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NF-kB Activation: Elucidating Upstream Events
NF-kB (Nuclear Factor-KappaB) is a heterodimeric protein composed of different combinations of members of the Rel family of transcription factors. The Rel/NF-kB family of transcription factors are inv...
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GPCRs: Exploring New Paradigms
As one of the largest and most diverse protein families in nature, the G-protein coupled receptor (GPCR) superfamily play important roles in a variety of biological and pathological processes such as ...
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GPR83: A Novel Treg Expressed Cell Surface Marker
GPR83 is a member of the Orphan-A G-Protein coupled receptor family, and has anunknown ligand. It has been previously reported in various regions of the brain, within a subset of T-lymphocytes, and by...
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Epigenetic and Signal Transduction Reagents
IMGENEX offers over 90 Chromatin, DNA Methylation & Repair, and DNA Fragmentation-related antibodies, many of which have been cited in numerous peer-reviewed journals. Find out more details in the fol...
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QuikChIP Chromatin Immunoprecipitation Kits
The principle of the ChIP assay is simple yet the process can be technically challenging. It is with these challenges in mind that IMGENEX developed the QuikChIP Kit for chromatin immunoprecipitation....
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Are we "Livin" or just "Survivin"?
Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. A novel CARD domain containing protein was recently identif...
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Apoptosis Programmed Cell Death
Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. A nov...
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